Basic information of RORC :
| Official Symbol of Gene | RORC |
| Species | Homo sapiens |
| Entrez Gene ID | 6097 |
| Official Full Name | RAR related orphan receptor C |
| Also known as | TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000143365 MIM:602943; AllianceGenome:HGNC:10260 |
| Map Location | 1q21.3 |
Sample information of multiple sclerosis:
| Detected Sample | meninges |
| Sample Detail | Ectopic B-cell follicle-like structures (ELS) |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | SPMS |
| Population | NA |
| Sample Size | 12MS |
Literature information of multiple sclerosis :
| Pubmed ID | 27413074 |
| Year | 2016 |
| Title | RORct Expression and Lymphoid Neogenesis in the Brain of Patients with Secondary Progressive Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Phenotypic risk |
| Result | Thus, there is selective migration or survival of RORct-positive cells in MS patient meninges and an association of these cells with ELS. |
| Mechanism/Pathway | Because cells expressing the transcriptional regulator reti-noic acid receptor-related orphan receptor-ct (RORct) and producing interleukin 17 (IL17), e.g. T helper 17 cells and lymphoid tissue in-ducer (LTi) cells, have been implicated in the formation of ELS, we studied RORct and IL17 expression in brain tissue from patients with SPMS an assessed their relationships to immune infiltrates and meningeal ELS. |
