Basic information of ROCK1 :
| Official Symbol of Gene | ROCK1 |
| Species | Homo sapiens |
| Entrez Gene ID | 6093 |
| Official Full Name | Rho associated coiled-coil containing protein kinase 1 |
| Also known as | ROCK-I; P160ROCK |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000067900 MIM:601702; AllianceGenome:HGNC:10251 |
| Map Location | 18q11.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | qRT-PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 30MS |
Literature information of multiple sclerosis :
| Pubmed ID | 36529069 |
| Year | 2022 |
| Title | Dysregulation of miR-193a serves as a potential contributor to MS pathogenesis via affecting RhoA and Rock1 |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Results showed that miR-193a was decreased while RhoA and ROCK1 were up-regulated in PBMCs obtained from patients with MS compared to the control group. It was also revealed that miR-193a transfection reduced RhoA and ROCK1 expression at mRNA and protein levels. |
| Mechanism/Pathway | At present, microRNAs (miRNAs) are considered not only a diagnostic and prognostic indicator of diseases but also a new goal in gene therapy. |
