Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 348 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
Sample information of multiple sclerosis:
| Detected Sample | CSF |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 121 MS/45 Health |
Literature information of multiple sclerosis :
| Pubmed ID | 9463752 |
| Year | 1998 |
| Title | Apolipoprotein E polymorphism in multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We recently demonstrated that apo E con-centrations in cerebrospinal fluid (CSF) and apo E intrathecal synthesis are decreased in MS patients. The reduction of CSF apo E levels may impair myelin repair and influence disease progression in MS patients. |
| Mechanism/Pathway | Apolipoprotein E (apo E) is a polymorphic plasma protein involved in cholesterol transport.Apo E is produced and secreted in the central nervous system by astrocytes. Following periph-eral nerve injury in rats, the synthesis of apo E increases 250- to 350-fold. A similar increase is observed in the central nervous system when the optic nerve and spinal cord are injured. It was suggested that apo E redistributes lipid, partici-pates in cholesterol homeostasis in the brain and is implicated in the growth and repair of the nervous system |
