Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
Sample information of multiple sclerosis:
| Detected Sample | CSF/peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PPMS/SPMS |
| Population | N/A |
| Sample Size | 50 MS/22Health |
Literature information of multiple sclerosis :
| Pubmed ID | 8887999 |
| Year | 1996 |
| Title | Gene polymorphism at position -308 of the tumor-necrosis-factor- (TNF-c ) in Multiple Sclerosis and it's influence on the regulation of TNF-c production |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Phenotypic risk |
| Result | Increased TNF-~ levels of cerebrospinal fluid (CSF) and peripheral blood were found in patients with chronic progressive MS and patients with acute relapses, but not in the stable form of the disease. |
| Mechanism/Pathway | Tumor-necrosis-factor-~ (TNF-c0 is a major mediator of the inflammatory immune response and may play an important role in the pathogenesis and progression of Multiple Sclerosis (MS). |
