Basic information of MMP-2 :
| Official Symbol of Gene | MMP-2 |
| Species | Homo sapiens |
| Entrez Gene ID | 4313 |
| Official Full Name | matrix metallopeptidase 2 |
| Also known as | CLG4; MONA; CLG4A; MMP-2; TBE-1; MMP-II |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000087245 MIM:120360; AllianceGenome:HGNC:7166 |
| Map Location | 16q12.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Kurdish ethnic background |
| Sample Size | 125 MS/235Health |
Literature information of multiple sclerosis :
| Pubmed ID | 27409770 |
| Year | 2016 |
| Title | Functional Promoter Polymorphisms of MMP-2 C-735T and MMP-9 C-1562T and Their Synergism with MMP-7 A-181G in Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In females the presence of MMP-2 C allele was associated with an increased risk of MS |
| Mechanism/Pathway | Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Matrix metalloproteinases (MMPs) play an important role in breakdown of blood–brain barrier, transmigration, and invasion of immune cells and formation of MS lesions. |
