Basic information of Kcna3 :
| Official Symbol of Gene | Kcna3 |
| Species | Homo sapiens |
| Entrez Gene ID | 16491 |
| Official Full Name | potassium voltage-gated channel, shaker-related subfamily, member 3 |
| Also known as | Mk-3; Kv1.3; Kca1-3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000047959 AllianceGenome:MGI:96660 |
| Map Location | 3 F2.3; 3 46.59 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | NA |
| Detected Method | qRT-PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | 3–5/cage |
Literature information of multiple sclerosis :
| Pubmed ID | 29574670 |
| Year | 2018 |
| Title | Voltage Gated Potassium Channel Kv1.3 Is Upregulated on Activated Astrocytes in Experimental Autoimmune Encephalomyelitis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Treatment risk |
| Result | Our results support the hypothesis that Kv1.3 may be a therapeutic target of interest for MS and add astrocytes to the list of cells whose activation would be suppressed by inhibiting Kv1.3 in inflammatory conditions. |
| Mechanism/Pathway | Kv1.3 is a voltage gated potassium channel that has been implicated in pathophysiology of multiple sclerosis (MS). |
