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Basic information of CCR5 :

Official Symbol of Gene CCR5
Species Homo sapiens
Entrez Gene ID 1234
Official Full Name C-C motif chemokine receptor 5
Also known as CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
Gene Type protein coding
dbXrefs Ensembl:ENSG00000160791 MIM:601373; AllianceGenome:HGNC:1606
Map Location 3p21.31

Sample information of multiple sclerosis:

Detected Sample CSF/peripheral blood
Sample Detail NA
Detected Method PCR
Disease MS
Disease subtype N/A
Population NA
Sample Size 148 MS/151Health

Literature information of multiple sclerosis :

Pubmed ID 10626673
Year 2000
Title CCR5 D32, matrix metalloproteinase-9 and disease activity in multiple sclerosis

Results of multiple sclerosis :

Expression up-regulation
Risk type Phenotypic risk
Result CCR5 D32, a truncated allele of the CC chemokine receptor CCR5 gene encoding a non-functional receptor, did
Mechanism/Pathway Chemokines and matrix metalloproteinases MMPs appear to be crucial in leukocyte recruitment to the central nervous system in .multiple sclerosis MS . CCR5 D32, a truncated allele of the CC chemokine receptor CCR5 gene encoding a non-functional receptor, did not confer protection from MS. CCR5 D32 was, however, associated with a lower risk of recurrent clinical disease activity