Basic information of MMP9 :

Official Symbol of Gene	MMP9
Species	Homo sapiens
Entrez Gene ID	4318
Official Full Name	matrix metallopeptidase 9
Also known as	GELB; CLG4B; MMP-9; MANDP2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000100985 MIM:120361; AllianceGenome:HGNC:7176
Map Location	20q13.12

Sample information of multiple sclerosis:

Detected Sample	CSF/peripheral blood
Sample Detail	NA
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	NA
Sample Size	148 MS/151Health

Literature information of multiple sclerosis :

Pubmed ID	10626673
Year	2000
Title	CCR5 D32, matrix metalloproteinase-9 and disease activity in multiple sclerosis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	High CSF levels of MMP-9 activity were also associated with recurrent disease activity.
Mechanism/Pathway	Chemokines and matrix metalloproteinases MMPs appear to be crucial in leukocyte recruitment to the central nervous system in .multiple sclerosis MS . CCR5 D32, a truncated allele of the CC chemokine receptor CCR5 gene encoding a non-functional receptor, did not confer protection from MS. CCR5 D32 was, however, associated with a lower risk of recurrent clinical disease activity