Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 348 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | NA |
| Sample Size | 47 MS |
Literature information of multiple sclerosis :
| Pubmed ID | 10593303 |
| Year | 1999 |
| Title | Preliminary Observations on APOE e4 Allele and Progression of Disability in Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Phenotypic risk |
| Result | These preliminary observations suggest that APOE genotype may influence disease progression in MS.The APOE e4 allele was not associated with an in-creased risk of MS or relapses. |
| Mechanism/Pathway | Apolipoprotein E expression is in-creased in regenerating neural tissue and the APOE e4 allele is associated with impaired neuronal repair. Since repair is essential for the restoration of central nervous system function following multiple sclerosis (MS) re-lapses, APOE genotype may influence clinical progres-sion of the disease. |
