Basic information of YTHDF1 :
| Official Symbol of Gene | YTHDF1 |
| Species | Homo sapiens |
| Entrez Gene ID | 54915 |
| Official Full Name | YTH N6-methyladenosine RNA binding protein F1 |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000149658 MIM:616529; AllianceGenome:HGNC:15867 |
| Map Location | 20q13.33 |
Sample information of multiple sclerosis:
| Detected Sample | CSF |
| Sample Detail | NA |
| Detected Method | qRT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | NA |
| Sample Size | 11MS/3no-MS |
Literature information of multiple sclerosis :
| Pubmed ID | 34294105 |
| Year | 2021 |
| Title | N6-Methyladenosine RNA modification in cerebrospinal fluid as a novel potential diagnostic biomarker for progressive multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Phenotypic risk |
| Result | The dynamic modification of m6A RNA methylation is involved in the progression of MS and could potentially represent a novel CSF biomarker for diagnosing MS and distinguishing PMS from RRMS in the early stages of the disease |
| Mechanism/Pathway | Previous studies have demonstrated that dysfunction of N6-methyladenosine (m6A) RNA modification is relevant to many neurological disorders. Thus, the aim of this study was to explore the diagnostic biomarkers for PMS based on m6A regulatory genes in the cerebrospinal fluid (CSF). |
