Basic information of CXCR4 :
| Official Symbol of Gene | CXCR4 |
| Species | Homo sapiens |
| Entrez Gene ID | 7852 |
| Official Full Name | C-X-C motif chemokine receptor 4 |
| Also known as | FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; WHIMS1; D2S201E |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000121966 MIM:162643; AllianceGenome:HGNC:2561 |
| Map Location | 2q22.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | qRT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | NA |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 33795012 |
| Year | 2021 |
| Title | Identification of blood-derived candidate gene markers and a new 7-gene diagnostic model for multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | RT-qPCR results demonstrated that CXCR4 was obviously up-regulated, while ACTB, RHOA, and ITGAM were down-regulated in MS patient PBMC in comparison with normal samples |
| Mechanism/Pathway | Multiple sclerosis (MS) is a central nervous system disease with a high disability rate. Modern molecular biology techniques have identified a number of key genes and diagnostic markers to MS, but the etiology and patho-genesis of MS remain unknown. |
