Basic information of ITGAM :
| Official Symbol of Gene | ITGAM |
| Species | Homo sapiens |
| Entrez Gene ID | 3684 |
| Official Full Name | integrin subunit alpha M |
| Also known as | CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000169896 MIM:120980; AllianceGenome:HGNC:6149 |
| Map Location | 16p11.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | qRT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | NA |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 33795012 |
| Year | 2021 |
| Title | Identification of blood-derived candidate gene markers and a new 7-gene diagnostic model for multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | RT-qPCR results demonstrated that CXCR4 was obviously up-regulated, while ACTB, RHOA, and ITGAM were down-regulated in MS patient PBMC in comparison with normal samples |
| Mechanism/Pathway | Multiple sclerosis (MS) is a central nervous system disease with a high disability rate. Modern molecular biology techniques have identified a number of key genes and diagnostic markers to MS, but the etiology and patho-genesis of MS remain unknown. |
