Basic information of IL21 :
| Official Symbol of Gene | IL21 |
| Species | Homo sapiens |
| Entrez Gene ID | 59067 |
| Official Full Name | interleukin 21 |
| Also known as | Za11; IL-21; CVID11 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000138684 MIM:605384; AllianceGenome:HGNC:6005 |
| Map Location | 4q27 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | qRT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | NA |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 31545959 |
| Year | 2019 |
| Title | IL-21 and IL-21-producing T cells are involved in multiple sclerosis severity and progression |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The results of our study suggest a pro-inflammatory and booster role for IL-21 in the MS pathogenesis and progression |
| Mechanism/Pathway | IL-21 is a proinflammatory cytokine produced mainly by Th-17 and Tfh cells which its exact role in MS was not yet clearly understood. In the present study we aimed to investigate the possible correlation of IL-21 gene expression, methylation, and its serum levels with MS severity and progres-sion. |
