Basic information of TCF4 :
| Official Symbol of Gene | TCF4 |
| Species | Homo sapiens |
| Entrez Gene ID | 6925 |
| Official Full Name | transcription factor 4 |
| Also known as | E2-2; FCD2; ITF2; PTHS; SEF2; CDG2T; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196628 MIM:602272; AllianceGenome:HGNC:11634 |
| Map Location | 18q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | q-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | NA |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 36250467 |
| Year | 2022 |
| Title | Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Most striking was the impaired TIGIT expression on MS-derived B cells mediated by dysregulation of the transcription factor TCF4. Activated circulating Tfh cells (cTfh cells) expressed CD155, the ligand of TIGIT , and TIGIT on B cells revealed their capacity to suppress the proliferation of IL -17–producing cTfh cells via the TIGIT/CD155 axis |
| Mechanism/Pathway | Here, we performed comprehensive analyses of CD40 ligand– (CD40L -) and IL -21–stimulated memory B cells from patients with MS and healthy age-matched controls, modeling the help of follicular helper T cells (Tfh cells), and found a differential gene expression signature in multiple B cell pathways. |
