Basic information of LTB :
| Official Symbol of Gene | LTB |
| Species | Homo sapiens |
| Entrez Gene ID | 4050 |
| Official Full Name | lymphotoxin beta |
| Also known as | p33; TNFC; TNFSF3; TNLG1C |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000227507 MIM:600978; AllianceGenome:HGNC:6711 |
| Map Location | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | q-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | NA |
| Sample Size | 39MS |
Literature information of multiple sclerosis :
| Pubmed ID | 22020419 |
| Year | 2012 |
| Title | Glatiramer acetate antibodies, gene expression and disease activity in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | High expression of mRNA encoding GATA3 and lymphotoxin-β ( LT-β) was associated with low disease activity in Gd-enhanced MRI studies. |
| Mechanism/Pathway | Glatiramer acetate (GA) treatment suppresses disease activity in multiple sclerosis (MS). The immunological response to treatment may differ in patients who are stable on GA therapy and patients with breakthrough disease activity, but the results of previous studies are inconsistent. |
