Basic information of MIR181A1 :
| Official Symbol of Gene | MIR181A1 |
| Species | Homo sapiens |
| Entrez Gene ID | 406995 |
| Official Full Name | microRNA 181a-1 |
| Also known as | MIR213; MIRN213; mir-213; MIRN181A1; mir-181a-1; hsa-mir-181a-1 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000207759 MIM:612742; miRBase:MI0000289; AllianceGenome:HGNC:31590 |
| Map Location | 1q32.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | qRT-PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | n = 10mice |
Literature information of multiple sclerosis :
| Pubmed ID | 26163591 |
| Year | 2015 |
| Title | mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Loss of mir-181a-1/b-1 dampened the induction of experimental autoimmune encephalomyelitis and reduced basal TCR signaling in peripheral T cells and their migration from lymph nodes to pathogenic sites. |
| Mechanism/Pathway | Here we show that genetic ablation of a natural tuner of TCR signaling, mir-181a-1/b-1, in double-positive (DP) thymocytes dampened TCR and Erk signaling and increased the threshold of positive selection. |
