Basic information of REG1A :
| Official Symbol of Gene | REG1A |
| Species | Homo sapiens |
| Entrez Gene ID | 5967 |
| Official Full Name | regenerating family member 1 alpha |
| Also known as | P19; PSP; PTP; REG; ICRF; PSPS; PSPS1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000115386 MIM:167770; AllianceGenome:HGNC:9951 |
| Map Location | 2p12 |
Sample information of multiple sclerosis:
| Detected Sample | cerebrospinal fluid |
| Sample Detail | NA |
| Detected Method | RT-qPCR |
| Disease | RRMS |
| Disease subtype | N/A |
| Population | RRMS |
| Sample Size | 5RRMS+5control |
Literature information of multiple sclerosis :
| Pubmed ID | 33876425 |
| Year | 2021 |
| Title | Temporal overexpression of IL-22 and Reg3γ differentially impacts the severity of experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | up-regulation |
| Mechanism/Pathway | IL- 22 induces production of four groups of Reg family pro- teins both in humans and in mice. These include Reg1, Reg2, Reg3a, Reg3b, Reg3 g, Reg3d and Reg4 in mice and REG1A, REG1B, REG3A, REG3B and REG4 in humans [27]. Reg proteins bind bacterial sugars and peptidoglycans through their C- type lectin domains (CTLD) via Ca2+- independent interactions and exert their bactericidal effects |
