Basic information of ID2 :

Official Symbol of Gene	ID2
Species	Homo sapiens
Entrez Gene ID	3398
Official Full Name	inhibitor of DNA binding 2
Also known as	GIG8; ID2A; ID2H; bHLHb26
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000115738 MIM:600386; AllianceGenome:HGNC:5361
Map Location	2p25.1

Sample information of multiple sclerosis:

Detected Sample	brain
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	34482420
Year	2021
Title	DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	ID2 and ID4 are hypomethylated and display increased expression in MS lesions, compared to controls.
Mechanism/Pathway	We conclude that DNA methylation is crucial to suppress ID2 and ID4 during OPC differentiation, a process that appears to be dysregulated during MS.