Basic information of MIR142 :
| Official Symbol of Gene | MIR142 |
| Species | Homo sapiens |
| Entrez Gene ID | 406934 |
| Official Full Name | microRNA 142 |
| Also known as | MIRN142; mir-142 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000284353 MIM:615657; miRBase:MI0000458; AllianceGenome:HGNC:31529 |
| Map Location | 17q22 |
Sample information of multiple sclerosis:
| Detected Sample | Brain |
| Sample Detail | white matter |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | non-MS patients (n = 6; mean age = 61 + 4.0 years; male:female, 3:3; diagnoses at death: sepsis, cancer, myocardial infarction, stroke, HIV-AIDS, Parkinson’s disease) and patients with MS (n = 6; mean age = 56 + 3.2 years; male:female, 2:4; diagnoses at death: secondary progressive MS (n = 4), primary progressive MS (n = 1) and relapsing-remitting MS (n = 1). |
Literature information of multiple sclerosis :
| Pubmed ID | 28302134 |
| Year | 2017 |
| Title | MicroRNA-142 regulates inflammation and T cell differentiation in an animal model of multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | disease risk |
| Result | miR-142 isoforms are upregulated in the CNS of MS patients and animals with EAE |
| Mechanism/Pathway | Our findings suggest that increased expression of miR-142 isoforms might be involved in the pathogenesis of autoimmune neuroinflammation by influencing T cell differentiation, and this effect could be mediated by interaction of miR-142 isoforms with SOCS1 and TGFBR-1 transcripts. |
