Basic information of SOCS1 :
| Official Symbol of Gene | SOCS1 |
| Species | Homo sapiens |
| Entrez Gene ID | 8651 |
| Official Full Name | suppressor of cytokine signaling 1 |
| Also known as | JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; AISIMD; SOCS-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000185338 MIM:603597; AllianceGenome:HGNC:19383 |
| Map Location | 16p13.13 |
Sample information of multiple sclerosis:
| Detected Sample | Brain |
| Sample Detail | white matter |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | non-MS patients (n = 6; mean age = 61 + 4.0 years; male:female, 3:3; diagnoses at death: sepsis, cancer, myocardial infarction, stroke, HIV-AIDS, Parkinson’s disease) and patients with MS (n = 6; mean age = 56 + 3.2 years; male:female, 2:4; diagnoses at death: secondary progressive MS (n = 4), primary progressive MS (n = 1) and relapsing-remitting MS (n = 1). |
Literature information of multiple sclerosis :
| Pubmed ID | 28302134 |
| Year | 2017 |
| Title | MicroRNA-142 regulates inflammation and T cell differentiation in an animal model of multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | disease risk |
| Result | In human autopsy samples, SOCS1 showed significant reduction in MS samples but the levels of TGFBR1 and TGFBR2 did not differ between MS and control tissues |
| Mechanism/Pathway | All these findings point to SOCS1 as a guardian of Tregs and a controller of Th1 development. |
