Basic information of GSDMB :
| Official Symbol of Gene | GSDMB |
| Species | Homo sapiens |
| Entrez Gene ID | 55876 |
| Official Full Name | gasdermin B |
| Also known as | GSDML; PP4052; GSDMB-1; PRO2521 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000073605 MIM:611221; AllianceGenome:HGNC:23690 |
| Map Location | 17q21.1 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 30 relapsing remitting (RR)-MS cases and 30 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 28272342 |
| Year | 2017 |
| Title | The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | disease risk |
| Result | Real-time RT-PCR performed on RNA extracted from PBMCs showed a significant upregulation of the GSDMB ecircRNA in MS cases with respect to controls (2.8-fold, p = 0.0011) (Figure 4d). |
| Mechanism/Pathway | Our results fit well with this hypothesis, and specifically provide evidence of alterations of GSDMB AS and backsplicing profiles in MS, highlighting a possible involvement of GSDMB isoform unbalance in the disease pathogenesis. |
