Basic information of MANBA :
| Official Symbol of Gene | MANBA |
| Species | Homo sapiens |
| Entrez Gene ID | 4126 |
| Official Full Name | mannosidase beta |
| Also known as | MANB1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000109323 MIM:609489; AllianceGenome:HGNC:6831 |
| Map Location | 4q24 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 152 MS patients,112 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 35897697 |
| Year | 2022 |
| Title | Impact of Multiple Sclerosis Risk Polymorphism rs7665090 on MANBA Activity, Lysosomal Endocytosis, and Lymphocyte Activation |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Decreased MANBA Expression and Enzymatic Activity in Lymphocytes from MS Patients Compared to Those from Healthy Controls |
| Mechanism/Pathway | We provide evidence regarding the MANBA gene as a contributor to MS susceptibility by investigating its role in the immunopathology of MS as well as the impact of the MS-associated SNP rs7665090. |
