Basic information of IL18 :
| Official Symbol of Gene | IL18 |
| Species | Homo sapiens |
| Entrez Gene ID | 3606 |
| Official Full Name | interleukin 18 |
| Also known as | IGIF; IL-18; IL-1g; IL1F4 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000150782 MIM:600953; AllianceGenome:HGNC:5986 |
| Map Location | 11q23.1 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 26743536 |
| Year | 2016 |
| Title | Use of the VH6-1 gene segment to code for anti-interleukin-18 autoantibodies in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | IL-18 concentration in MS patients' sera was higher than in HD, but the level of anti-IL-18 auto-Abs was lower in MS patients. |
| Mechanism/Pathway | These variations from the norm are possible results of abnormal regulation of the repertoire perhaps determined by remodeling of the molecular mechanisms involved in the V(D)J recombination and/or abnormal selection by antigen in MS pathogenesis. |
