Basic information of MAGI2-AS3 :
| Official Symbol of Gene | MAGI2-AS3 |
| Species | Homo sapiens |
| Entrez Gene ID | 100505881 |
| Official Full Name | MAGI2 antisense RNA 3 |
| Also known as | N/A |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000234456 AllianceGenome:HGNC:40862 |
| Map Location | 7q21.11 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | RT-Qpcr |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 100 patients with MS and 50 healthy volunteers |
Literature information of multiple sclerosis :
| Pubmed ID | 36878000 |
| Year | 2023 |
| Title | MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN/AKT/IRF-3/IFN-β Axis: New Clinical Insights |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Compared with the healthy control group, serum MAGI2-AS3 and PTEN were downregulated in MS patients, whereas miR-374b-5p, PI3K, AKT, IRF-3, and IFN-β were upregulated in MS patients. |
| Mechanism/Pathway | In conclusion, the study showed for the first time that the crosstalk between MAGI2-AS3 and miR-374b-5p could affect the AKT/IRF3/IFN-β axis in MS. |
