Basic information of PSMB8 :
| Official Symbol of Gene | PSMB8 |
| Species | Homo sapiens |
| Entrez Gene ID | 5696 |
| Official Full Name | proteasome 20S subunit beta 8 |
| Also known as | JMP; ALDD; LMP7; NKJO; D6S216; PRAAS1; PSMB5i; RING10; D6S216E |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204264 MIM:177046; AllianceGenome:HGNC:9545 |
| Map Location | 6p21.32 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | Seventy-eight RRMS patients treated with IFNβ-1a and 79 age- and ethnic-matched healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 29157944 |
| Year | 2018 |
| Title | Down-regulation of TYK2, CBLB and LMP7 genes expression in relapsing-remitting multiple sclerosis patients treated with interferon-beta |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Significantly down-regulated expression of TYK2, CBLB and LMP7 genes was found in the patients group versus controls. |
| Mechanism/Pathway | Our results suggest that expression analysis of TYK2, CBLB and LMP7 genes could be useful for evaluation of T cells immunity and clinical response to IFNβ-therapy in RRMS patients. |
