Basic information of CX3CL1 :
| Official Symbol of Gene | CX3CL1 |
| Species | Homo sapiens |
| Entrez Gene ID | 6376 |
| Official Full Name | C-X3-C motif chemokine ligand 1 |
| Also known as | NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000006210 MIM:601880; AllianceGenome:HGNC:10647 |
| Map Location | 16q21 |
Sample information of multiple sclerosis:
| Detected Sample | blood,CSF |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 53 RRMS,10 (CIS), 19 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 25596452 |
| Year | 2015 |
| Title | The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Our results also identified higher CX3XL1 levels in the serum samples from 38 RRMS patients than in 38 HCs and higher serum levels in comparison to the CSF |
| Mechanism/Pathway | Thus, CX3CL1 induces recruitment of CX3CR1(+)ICAM-1(+)CD4(+) T-cells into the central nervous system (CNS) during the early inflammatory response in MS. |
