Basic information of MIR17 :

Official Symbol of Gene	MIR17
Species	Homo sapiens
Entrez Gene ID	406952
Official Full Name	microRNA 17
Also known as	MIR91; MIRN17; MIRN91; miR-17; miRNA17; miRNA91; MIR17-5p; miR17-3p; hsa-mir-17
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000284536 MIM:609416; miRBase:MI0000071; AllianceGenome:HGNC:31547
Map Location	13q31.3

Sample information of multiple sclerosis:

Detected Sample	blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	RRMS
Population	N/A
Sample Size	fourteen untreated, fourteen natalizumab treated (mean time of treatment duration: 18 months) relapsing-remitting MS patients, and fourteen age and gender matched healthy volunteers

Literature information of multiple sclerosis :

Pubmed ID	24901013
Year	2014
Title	Unraveling natalizumab effects on deregulated miR-17 expression in CD4+ T cells of patients with relapsing-remitting multiple sclerosis

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	miR-17 was downregulated under natalizumab treatment and upregulated during relapse, therefore supporting a possible role of miR-17 in MS immunopathogenesis.
Mechanism/Pathway	Specific inhibition of miR-17 in CD4 T cells resulted in a significant impairment of cell proliferation upon in vitro CD3/CD28 stimulation (++Figure 5(b) left and middle panels), suggesting an important role of miR-17 on lymphocyte proliferation.