Basic information of MIR548AC :
| Official Symbol of Gene | MIR548AC |
| Species | Homo sapiens |
| Entrez Gene ID | 100616384 |
| Official Full Name | microRNA 548ac |
| Also known as | N/A |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000264419 miRBase:MI0016762; AllianceGenome:HGNC:41626 |
| Map Location | 1p13.1 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | RT–PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | north-east Germany. |
| Sample Size | 32 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 30730892 |
| Year | 2019 |
| Title | A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | To conclude, the MS-associated haplotype is implicated with significantly decreased CD58 mRNA levels (HapMap cohort and Geuvadis cohort data). |
| Mechanism/Pathway | We provide evidence that the SNP rs1414273 might alter Drosha cleavage activity, thereby provoking partial uncoupling of CD58 gene expression and microRNA-548ac production from the shared primary transcript in immune cells. |
