Basic information of CD58 :
| Official Symbol of Gene | CD58 |
| Species | Homo sapiens |
| Entrez Gene ID | 965 |
| Official Full Name | CD58 molecule |
| Also known as | ag3; LFA3; LFA-3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000116815 MIM:153420; AllianceGenome:HGNC:1688 |
| Map Location | 1p13.1 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | RT–PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | north-east Germany. |
| Sample Size | 32 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 30730892 |
| Year | 2019 |
| Title | A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | On the other hand, significantly increased levels of hsa-miR-548ac can be seen in risk allele carriers (Geuvadis cohort and MS cohort data). |
| Mechanism/Pathway | Moreover, the microRNA was found to regulate genes, which participate in inflammatory processes and in controlling the balance of protein folding and degradation. |
