Basic information of GPR183 :
| Official Symbol of Gene | GPR183 |
| Species | Homo sapiens |
| Entrez Gene ID | 1880 |
| Official Full Name | G protein-coupled receptor 183 |
| Also known as | EBI2; Hebi2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000169508 MIM:605741; AllianceGenome:HGNC:3128 |
| Map Location | 13q32.3 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood mononuclear cells |
| Detected Method | flow cytometry |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | HDs (n = 16) and RRMS patients (n = 15) |
Literature information of multiple sclerosis :
| Pubmed ID | 28052250 |
| Year | 2017 |
| Title | EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | We observed that EBI2 is functionally expressed on memory CD4 T cells and is enhanced under natalizumab treatment. |
| Mechanism/Pathway | These data suggest a significant role for EBI2 in human CD4 T cell migration, notably in patients with MS. |
