Basic information of P2RY12 :
| Official Symbol of Gene | P2RY12 |
| Species | Homo sapiens |
| Entrez Gene ID | 64805 |
| Official Full Name | purinergic receptor P2Y12 |
| Also known as | HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc) |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000169313 MIM:600515; AllianceGenome:HGNC:18124 |
| Map Location | 3q25.1 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | Blood Platelets and Megakaryocytes |
| Detected Method | TaqMan |
| Disease | MS |
| Disease subtype | SPMS |
| Population | N/A |
| Sample Size | SPMS patients (n = 55) and from control group (n = 55) |
Literature information of multiple sclerosis :
| Pubmed ID | 34207429 |
| Year | 2021 |
| Title | The Molecular Aspects of Disturbed Platelet Activation through ADP/P2Y12 Pathway in Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Simultaneously, the level of relative expression of mRNA transcripts for the P2RY12 gene in megakaryocytes was 85% higher in SP MS compared to the control group |
| Mechanism/Pathway | Positive correlations between P2Y12 cellular expression and the level of activation markers formed analogously to the exposure of platelets to thrombin may provide evidence for the influence of the PAR1 receptor pathway on ADP/P2Y12 signaling. Go to: 4. Materials and Methods |
