Basic information of SIRPG :
| Official Symbol of Gene | SIRPG |
| Species | Homo sapiens |
| Entrez Gene ID | 55423 |
| Official Full Name | signal regulatory protein gamma |
| Also known as | CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089012 MIM:605466; AllianceGenome:HGNC:15757 |
| Map Location | 20p13 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | T-cells |
| Detected Method | flow cytometry |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size |
33 treatment na |
Literature information of multiple sclerosis :
| Pubmed ID | 32853219 |
| Year | 2020 |
| Title | Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | T-cells from RRMS and T1D patients have significantly reduced SIRPγ expression as compared to HD. |
| Mechanism/Pathway | Interestingly, increased frequencies of SIRPγlow T-cells in RRMS and T1D positively correlated with proinflammatory molecules from T-cells. |
