Basic information of CNR2 :
| Official Symbol of Gene | CNR2 |
| Species | Homo sapiens |
| Entrez Gene ID | 1269 |
| Official Full Name | cannabinoid receptor 2 |
| Also known as | CB2; CX5; CB-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000188822 MIM:605051; AllianceGenome:HGNC:2160 |
| Map Location | 1p36.11 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | RT–PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | Twenty-six patients with relapsing–remitting MS,21 healthy volunteers |
Literature information of multiple sclerosis :
| Pubmed ID | 25169051 |
| Year | 2015 |
| Title | Regulation of cannabinoid receptor gene expression and endocannabinoid levels in lymphocyte subsets by interferon-β: a longitudinal study in multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Prior to interferon therapy, MS patients showed significantly elevated CB2 expression in B cells, but not in T or NK cells. |
| Mechanism/Pathway | The different expression of cannabinoid receptor genes and the increased level of AEA in lymphocytes point to a possible role of the cannabinoid system in MS immune response and its modulation by interferon. |
