Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS |
| Population | N/A |
| Sample Size | 42 CON,32 PPMS, 21 RRMS subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 17928869 |
| Year | 2007 |
| Title | Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We found that CD127 mRNA expression was significantly reduced in whole blood samples from PPMS patients. |
| Mechanism/Pathway | CD127 expression may be a biomarker for these potentially pathologically significant leukocyte types. These significant haplotypic effects on expression are likely to modulate regulation, differentiation and function of T cell subsets in health and disease. |
