Basic information of IL23A :
| Official Symbol of Gene | IL23A |
| Species | Homo sapiens |
| Entrez Gene ID | 51561 |
| Official Full Name | interleukin 23 subunit alpha |
| Also known as | P19; SGRF; IL-23; IL-23A; IL23P19 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000110944 MIM:605580; AllianceGenome:HGNC:15488 |
| Map Location | 12q13.3 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | CD4+ T cells |
| Detected Method | RT–PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 42 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 33884734 |
| Year | 2021 |
| Title | CD4+ and CD25+ T-cell response to short-time interferon-beta therapy on IL10, IL23A and FOXP3 genes in multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | When we performed RT-PCR for IL23A gene expression profile of CD4+ T cells, it was observed that gene was significantly down-regulated at the 48 hours of drug exposure. |
| Mechanism/Pathway | Although this study did not mention any discrimination on genes we investigated here, it pointed out the minimal short-time effects on Th1/Th2 pathways which are known to be highly related to CD4+ and CD25+ T-cell metabolism |
