Basic information of FOXP3 :
| Official Symbol of Gene | FOXP3 |
| Species | Homo sapiens |
| Entrez Gene ID | 50943 |
| Official Full Name | forkhead box P3 |
| Also known as | JM2; AIID; IPEX; PIDX; XPID; DIETER |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000049768 MIM:300292; AllianceGenome:HGNC:6106 |
| Map Location | Xp11.23 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | CD4+ T cells |
| Detected Method | RT–PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 42 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 33884734 |
| Year | 2021 |
| Title | CD4+ and CD25+ T-cell response to short-time interferon-beta therapy on IL10, IL23A and FOXP3 genes in multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | FOXP3 gene expression in CD4+ was significantly increased at 48 hours post-administration |
| Mechanism/Pathway | Although this study did not mention any discrimination on genes we investigated here, it pointed out the minimal short-time effects on Th1/Th2 pathways which are known to be highly related to CD4+ and CD25+ T-cell metabolism |
