Basic information of MT-ND6 :
| Official Symbol of Gene | MT-ND6 |
| Species | Homo sapiens |
| Entrez Gene ID | 4541 |
| Official Full Name | mitochondrially encoded NADH dehydrogenase 6 |
| Also known as | MTND6; ND6 |
| Gene Type | protein coding |
| dbXrefs | MIM:516006; AllianceGenome:HGNC:7462 |
| Map Location | N/A |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood mononuclear cells |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 11 MS patients,10 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 28460056 |
| Year | 2017 |
| Title | Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Similarly, DMF treated MS patients’ shows significant increase in mitochondrial complex subunit expression of mt-ND6 (complex 1), mt-CYB (complex 3), mt-CO2 (complex 4) and mt-ATP6 (complex 5) by 3.13 fold (P < 0.0358, n = 12), 2.87 fold (P < 0.016, n = 12), 2.34 fold (P < 0.041, n = 12) and 3.74 fold (P < 0.014, n = 12) respectively, when normalized to its own baseline. |
| Mechanism/Pathway | Thus, DMF induces mitochondrial biogenesis primarily through its action on Nrf2, and is the first drug demonstrated to increase mitochondrial biogenesis with in vivo human dosing. |
