Basic information of NLRC4 :

Official Symbol of Gene	NLRC4
Species	Homo sapiens
Entrez Gene ID	58484
Official Full Name	NLR family CARD domain containing 4
Also known as	CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000091106 MIM:606831; AllianceGenome:HGNC:16412
Map Location	2p22.3

Sample information of multiple sclerosis:

Detected Sample	blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	30 MS patients

Literature information of multiple sclerosis :

Pubmed ID	27032392
Year	2016
Title	The Effects of IFN-β 1a on the Expression of Inflammasomes and Apoptosis-Associated Speck-Like Proteins in Multiple Sclerosis Patients

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	Analysis of the results before and after therapy with IFN-β 1α in all patients shows significantly decreased expressions of NLRP3, NLRC4, and AIM2.
Mechanism/Pathway	Based on our results, it appears that NLRP3, NLRC4, and AIM2 play critical roles in the progression of MS, probably by mediating Th1 and Th17 responses.