Basic information of AIM2 :
| Official Symbol of Gene | AIM2 |
| Species | Homo sapiens |
| Entrez Gene ID | 9447 |
| Official Full Name | absent in melanoma 2 |
| Also known as | PYHIN4 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000163568 MIM:604578; AllianceGenome:HGNC:357 |
| Map Location | 1q44 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 30 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 27032392 |
| Year | 2016 |
| Title | The Effects of IFN-β 1a on the Expression of Inflammasomes and Apoptosis-Associated Speck-Like Proteins in Multiple Sclerosis Patients |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Analysis of the results before and after therapy with IFN-β 1α in all patients shows significantly decreased expressions of NLRP3, NLRC4, and AIM2. |
| Mechanism/Pathway | Based on our results, it appears that NLRP3, NLRC4, and AIM2 play critical roles in the progression of MS, probably by mediating Th1 and Th17 responses. |
