Basic information of SOCS1 :
| Official Symbol of Gene | SOCS1 |
| Species | Homo sapiens |
| Entrez Gene ID | 8651 |
| Official Full Name | suppressor of cytokine signaling 1 |
| Also known as | JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; AISIMD; SOCS-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000185338 MIM:603597; AllianceGenome:HGNC:19383 |
| Map Location | 16p13.13 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 50 RRMS,50 age and gender matched |
Literature information of multiple sclerosis :
| Pubmed ID | 28196747 |
| Year | 2017 |
| Title | SOCS gene family expression profile in the blood of multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We observed that SOCS1 and SOCS5 expression was significantly down-regulated. |
| Mechanism/Pathway | In fact, all SOCS proteins can regulate JAK-STAT pathway and can be involved in autoimmune diseases, but due to the importance of studied SOCS proteins (SOCS1, 2, 3 and 5) as well as limitations that we had, it was not possible for us to analyze other SOCS proteins. |
