Basic information of MIR128 :

Official Symbol of Gene	MIR128
Species	Homo sapiens
Entrez Gene ID	102464793
Official Full Name	microRNA mir-128
Also known as	sha-mir-128
Gene Type	ncRNA
dbXrefs	Ensembl:ENSSHAG00000028886 miRBase:MI0019625
Map Location	chromosome: 3

Sample information of multiple sclerosis:

Detected Sample	Blood
Sample Detail	Peripheral blood mononuclear cells
Detected Method	PCR
Disease	MS
Disease subtype	PPMS,RRMS,SPMS
Population	N/A
Sample Size	healthy donors (n = 16) or treatment-nave patients with multiple sclerosis (n = 22), falling into the primary progressive (n = 5), relapsing–remitting (n = 12) or secondary progressive (n = 5) categories

Literature information of multiple sclerosis :

Pubmed ID	22088562
Year	2011
Title	Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity

Results of multiple sclerosis :

Expression	up-regulation
Risk type	disease risk
Result	miR-128 and miR-27b were increased in nave and miR-340 in memory CD4(+) T cells from patients with multiple sclerosis, inhibiting Th2 cell development and favouring pro-inflammatory Th1 responses.
Mechanism/Pathway	These effects were mediated by direct suppression of B lymphoma Mo-MLV insertion region 1 homolog (BMI1) and interleukin-4 (IL4) expression, resulting in decreased GATA3 levels, and a Th2 to Th1 cytokine shift. Gain-of-function experiments with these micro-RNAs enhanced the encephalitogenic potential of myelin-specific T cells in experimental autoimmune encephalomyelitis.