Basic information of ABCB1 :
| Official Symbol of Gene | ABCB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 5243 |
| Official Full Name | ATP binding cassette subfamily B member 1 |
| Also known as | CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; p-170 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000085563 MIM:171050; AllianceGenome:HGNC:40 |
| Map Location | 7q21.12 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | peripheral blood mononuclear cells |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Germany |
| Sample Size | 832 multiple sclerosis patients from three sites in Germany (Go¨ttingen, n = 166; Rostock, n = 423, Berg, n = 194) |
Literature information of multiple sclerosis :
| Pubmed ID | 19605531 |
| Year | 2009 |
| Title | ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | disease risk |
| Result | In conclusion, SNPs in ABC-transporter genes may serve as pharmacogenetic markers associated with clinical response to MX therapy in multiple sclerosis. |
| Mechanism/Pathway | ATP-binding cassette-transporters ABCB1 and ABCG2 represent multi-drug resistance mechanisms involved in active cellular MX efflux. |
