Basic information of ERVW-1 :

Official Symbol of Gene	ERVW-1
Species	Homo sapiens
Entrez Gene ID	30816
Official Full Name	endogenous retrovirus group W member 1, envelope
Also known as	ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525
Map Location	7q21.2

Sample information of multiple sclerosis:

Detected Sample	tumor/normal adjacent tissues and various areas of brain tissues
Sample Detail	N/A
Detected Method	RT-PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	18604468
Year	2008
Title	Quantitative expression of the HERV-W env gene in human tissues

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	In silico expression data indicated that 14 complete HERV-W families from human chromosomes 1, 2, 4, 7, 8, 11, 13, 15, and Y are randomly expressed in various cancer tissues. HERV-Wenv transcripts did not show significant differences among the human tumor/normal adjacent tissues (colon, liver, uterus, breast, and stomach). Quantitative real-time RT-PCR analysis indicated that strong expression of the HERV-W env gene was detected in the cerebral cortex and pons of the human brain.
Mechanism/Pathway	Full-length retroviral sequences may interact with cellular oncogenes, and retroviral long terminal repeat (LTR) elements have the capacity to exert regulatory influences as promoters and enhancers of cellular genes