Basic information of ERVW-1 :

Official Symbol of Gene	ERVW-1
Species	Homo sapiens
Entrez Gene ID	30816
Official Full Name	endogenous retrovirus group W member 1, envelope
Also known as	ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525
Map Location	7q21.2

Sample information of multiple sclerosis:

Detected Sample	human astrocytes and in human umbilical vein endothelial cells
Sample Detail	N/A
Detected Method	QPCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	25976174
Year	2015
Title	A Novel, Highly Selective RT-QPCR Method for Quantification of MSRV Using PNA Clamping Syncytin-1 (ERVWE1)

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Using our newly developed method we confirmed that the expression of MSRV takes place in normal human astrocytes and in human umbilical vein endothelial cells in vitro. We also found that the stimulation of human monocytes did not influence the specific expression of MSRV but it caused changes in mRNA level of distinct HERV-W templates
Mechanism/Pathway	Both ERVWE1 and MSRV mRNA share high level of similarity and hence a method that allows to exclusively quantify the MSRV expression in clinical samples would be desirable. We developed a quantitative polymerase chain reaction (QPCR) technique for the detection and quantification of the multiple sclerosis-associated retrovirus. The assay utilises fluorescently labelled oligonucleotide probe, which is complementary to the conservative fragment of MSRV env gene and a peptide nucleic acid (PNA) probe, fully complementary to the ERVWE1 sequence fragment that efficiently blocks the polymerase action on ERVWE1 templates. The PNA molecule, if used parallel with hydrolysis probe in QPCR analysis, greatly facilitates the detection efficiency of MSRV even if ERVWE1 is present abundantly in respect to MSRV in the analysed sample. We achieved a wide and measurable range from 1 9 10 e2 to 1 9 10 e8 copies/reaction; the linearity of the technique was maintained even at the low MSRV level of 1 % in respect to ERVWE1.