Basic information of CD4 :
| Official Symbol of Gene | CD4 |
| Species | Homo sapiens |
| Entrez Gene ID | 920 |
| Official Full Name | CD4 molecule |
| Also known as | T4; IMD79; Leu-3; OKT4D; CD4mut |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000010610 MIM:186940; AllianceGenome:HGNC:1678 |
| Map Location | 12p13.31 |
Sample information of multiple sclerosis:
| Detected Sample | splenocytes |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 12231211 |
| Year | 2002 |
| Title | Study of Disabling T-Cell Activation and Inhibiting T-Cell-Mediated Immunopathology Reveals a Possible Inverse Agonist Activity of CD4 Peptidomimetics |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | We propose that CD4-Cys and CD4-Ser are classical antagonists, but CD4-Met may possess properties of an inverse agonist. The structure– activity relationship of mimetics reveals that a minor change in the net hydropathic value is enough to alter the dynamic nature of the receptor– ligand complex |
| Mechanism/Pathway | CD4-Ser and CD4-Cys mimetics reduced the severity of EAE symptoms while the CD4-Met mimetic exacerbated the conditions |
