Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Sardinia |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 15149631 |
| Year | 2004 |
| Title | High frequency of TNF alleles -238A and -376A in individuals from northern Sardinia |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | These findings indicate that Sardinia is an ideal location to further elucidate the correlation between TNF or HLA polymorphisms and diseases, including multiple sclerosis and type-I diabetes, present with an unusually high frequency and co-morbidity in Sardinia |
| Mechanism/Pathway | On the basis of this rationale, a number of single nucleotide polymorphisms (SNPs) in the promoter region of the TNF gene have been investigated for their effects on gene transcription as well as for their possible correlation with a particular disease |
