Basic information of CCL1 :
| Official Symbol of Gene | CCL1 |
| Species | Homo sapiens |
| Entrez Gene ID | 6346 |
| Official Full Name | C-C motif chemokine ligand 1 |
| Also known as | P500; SISe; TCA3; I-309; SCYA1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000108702 MIM:182281; AllianceGenome:HGNC:10609 |
| Map Location | 17q12 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | plasma |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | Plasma samples from 31 patients with HAM/TSP, 13 HTLV-1-seronegative patients with multiple sclerosis (MS), 19 HTLV-1- infected asymptomatic healthy carriers (HCs), and 10 HTLV-1-uninfected normal control subjects (NCs) |
Literature information of multiple sclerosis :
| Pubmed ID | 29202792 |
| Year | 2017 |
| Title | The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Plasma levels of CCL1 were significantly higher in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) than in HTLV-1-seronegative patients with multiple sclerosis (MS) and asymptomatic HTLV-1 healthy carriers (HC). |
| Mechanism/Pathway | minocycline inhibited the production of CCL1 in a dose dependent manner in HTLV-1- infected T-cell lines. |
