Basic information of IL27 :
| Official Symbol of Gene | IL27 |
| Species | Homo sapiens |
| Entrez Gene ID | 246778 |
| Official Full Name | interleukin 27 |
| Also known as | p28; IL30; IL-27; IL27A; IL-27A; IL27p28 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000197272 MIM:608273; AllianceGenome:HGNC:19157 |
| Map Location | 16p12.1-p11.2 |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | N/A |
| Population | Roman |
| Sample Size | 51 patients diagnosed with MS / 31 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 34410977 |
| Year | 2021 |
| Title | IL27 T4730C Polymorphism and Serology in Multiple Sclerosis: A Pilot Study |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | IL27 levels were significantly lower in patients compared to controls. |
| Mechanism/Pathway | IL27 is a novel member of the IL12 family, known for both its pro- and anti-inflammatory functions, with distinct roles in shaping the activity of T-cells. IL27 regulates the immune response through its heterodimeric IL27Ra/GP130 receptor, activating multiple signaling cascades.In the brain, IL27 produced by astrocytes and microglial cells is recognized for its neuroprotective effects, enhancing the production of nerve growth factor and neurotrophic factor, promoting remyelination. |
