Basic information of C3 :

Official Symbol of Gene	C3
Species	Homo sapiens
Entrez Gene ID	718
Official Full Name	complement C3
Also known as	ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000125730 MIM:120700; AllianceGenome:HGNC:1318
Map Location	19p13.3

Sample information of multiple sclerosis:

Detected Sample	serum
Sample Detail	N/A
Detected Method	single radial immunodiffusion with monospecific sera
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	88 MS patients / 52 controls

Literature information of multiple sclerosis :

Pubmed ID	886365
Year	1977
Title	Hypocomplementaemic and normocomplementaemic multiple sclerosis. Genetic determinism and association with specific HLA determinants (B18 and B7)

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	The frequency of low C3 is significantly higher in MS than that found in the normal group.
Mechanism/Pathway	We recently suggested that hypocomplementaemic MS is a specific form of the disease.The hypocomplementaemic population is statistically associated with low factor B and IgG levels, a low cerebrospinal fluid (CSF) IgG ratio, a pure remittent form of evolution, early age of onset, increased frequency of infectious events prior to MS and a fairly benign prognosis.