Basic information of CFB :

Official Symbol of Gene	CFB
Species	Homo sapiens
Entrez Gene ID	629
Official Full Name	complement factor B
Also known as	BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000243649 MIM:138470; AllianceGenome:HGNC:1037
Map Location	6p21.33

Sample information of multiple sclerosis:

Detected Sample	serum
Sample Detail	N/A
Detected Method	single radial immunodiffusion with monospecific sera
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	88 MS patients / 52 controls

Literature information of multiple sclerosis :

Pubmed ID	886365
Year	1977
Title	Hypocomplementaemic and normocomplementaemic multiple sclerosis. Genetic determinism and association with specific HLA determinants (B18 and B7)

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	Factor B is low in 63.3 % of the cases.
Mechanism/Pathway	We recently suggested that hypocomplementaemic MS is a specific form of the disease.The hypocomplementaemic population is statistically associated with low factor B and IgG levels, a low cerebrospinal fluid (CSF) IgG ratio, a pure remittent form of evolution, early age of onset, increased frequency of infectious events prior to MS and a fairly benign prognosis.